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Biography

Hoda EL-Attar has completed her MBBS in 11/1979, MS in Chemical Pathology 4/1987 ,MD in Chemical Pathology in 4/2001. She worked as an assistant Professor in Chemical Pathology from 28/8/2006 .Now She is working as a professor in Chemical Pathology since 30/8/2011 in Alexandria University Egypt. She is a member of the European Society of Cardiology (ESC): Working Group on Atherosclerosis and Vascular Biology. She has published 27 papers.

Abstract

Background:
The first cloned long pentraxin is Pentraxin 3(PTX3) and C-reactive  protein is a human short pentraxin. Pentraxin 3 has a bigger molecular size (40.6 KDa) compared to CRP (21.5 KDa).The long PTX3 is produced by diverse cell types in response to primary inflammatory signals and specific neutrophil granules store PTX3 .

 Aim:
Evaluation of serum levels of long Pentraxin 3 and high sensitivity C-reactive protein in patients with chronic  kidney disease treated with or without haemodialysis.

The study included 75 subjects,25 heathy controls(group1),50 patients without cardiovascular disease subdivided into:25 patients with chronic kidney disease (CKD) on conservative therapy(group 2a) and 25CKD patients on maintenance hemodialysis (group2b).To all studied subjects the following was done :electocardiography,carotid intima media thickness, fasting serum glucose ,renal, liver and lipid profiles,high- sensitivity C-reactive protein (hsCRP) and PTX3by ELISA.

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