Huda Mohammad Alshammari

King Saud University, Saudi Arabia

Title: Impact of Antibiotic Stewardship Programs on Clostridium difficile infections (CDIs)


Salman Abdulaziz graduated from King Saud University, Saudi Arabia. He had his clinical training of Internal Medicine in King Fahad National Guard Hospital in Riyadh from (2002-2006). He had Arab board, Saudi board, MRCP(UK) of Internal Medicine in 2006. He got the Saudi Board of Critical Care from King Faisal Specialist Hospital and Research Center in year 2012. He is an active member of Quality Improvement Committee in Global Sepsis Alliance. He is the chairperson of Sepsis clinical guidelines protocol and pathway Taskforce in Rashid Hospital in Dubai, where he works currently as a consultant of Internal Medicine and Critical Care.


Clostridium difficile infections (CDIs) had become of major burden on healthcare system. These infections are the result of collateral damage to the normal bacterial flora of the human body, which is an inevitable complication of antibiotics use. CDIs pose immediate threat to the health of patients received antibiotics, more so than antimicrobial resistance. 

Considering CDIs are nearly always complications of antibiotics use, the development of program to ensure appropriate antibiotics use is considered an important prevention intervention. Multidisciplinary managed program such as antimicrobial stewardship has been initiated in health care facilities to control the misuse of antimicrobial therapies and reduce their complications. Clinical pharmacist involved antimicrobial ward-round is designed to help limit CDIs and other hospital-associated organisms by optimizing antimicrobial selection, dosing, de-escalation, and duration of antimicrobial therapy. Other activates such as audit with feedback and antibiotic restriction also have been established to impact on the antimicrobial utilization. These programs also incorporate implementation of hospital-wide guidelines, staff education, enforcement of infection-control policies, and the use of electronic medical records when possible to help control antimicrobial use. 

The literature strongly emphasize on how antimicrobial stewardship programs impact on CDIs rates discusses experiences in designing, implementing, monitoring, and follow-through of such programs. Literature shows significant decrease in the use of parenteral broad-spectrum antibiotic and in incidence of CDIs.