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Biography

Dr. Imran Ali Khan has completed his Ph.D at the age of 27 years from Osmania University and presently joined as postdoctoral studies in King Saud University. He has published more than 47 publications in reputed journals. Presently, he is working with multiple projects on relationship between consanguinity and metabolic disorders.

Abstract

The paraoxonase 1 (PON1) gene polymorphism Q192R has been found to be consistent with multiple metabolic diseases comprising type 2 diabetes mellitus (T2DM). The R allele has been found to be associated with coronary artery disease and gestational diabetes in a Saudi population. Therefore, we attempted to determine the association between Q192R and T2DM in a Saudi population. Eight hundred subjects were enrolled in this case-control study, including T2DM patients (n = 400) and control individuals (n = 400). Epidemiological, clinical, and Q192R genotype data were obtained from all the subjects included in this study. Genotyping was performed by PCR-RFLP analysis followed by 12% polyacrylamide agarose gel electrophoresis. Most of the clinical characteristics of T2DM were associated with controls, having positive association with allele and genotype frequencies between the T2DM cases and controls (p < 0.05). Multiple regression analysis showed positive correlation of lipid profile with genotype (p < 0.05). The present findings provide robust evidence of PON1 Q192R polymorphism being associated with T2DM in a Saudi population.