The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Dr. Estrella has completed her MD in 2005 from the University of California, San Diego School of Medicine. She completed her Anatomic pathology residency at New York Presbyterian – Weill Cornell Medical College in New York, NY, and Oncologic pathology fellowship and Gastrointestinal tract and Liver pathology fellowship at MD Anderson in Houston, TX. She is an associate professor at MD Anderson in the GI and Liver section. She is the primary investigator, co-primary investigator or collaborator in 6 institutional or national research grants. She has published 43 papers in peer-reviewed journals.
Pancreatic neuroendocrine neoplasms (PanNETs) are rare, representing approximately 3% of primary pancreatic neoplasms, although their incidence has risen sharply in the United States, increasing more than 100% over the past three decades. In the past, classification of PanNETs has been fraught with different nomenclature and multiple grading and staging systems. The 2010 WHO Classification of Tumours of the Digestive System and the 7th edition of AJCC Cancer Staging Manual have tried to address these issues, however, controversies still exist. This lecture will address the current grading and staging systems, issues encountered in everyday practice, clinical significance and future direction.