Luciana Ximenes

Luciana Ximenes

Federal University of Ceara, Brazil

Title: Antidepressant like effect of Citronellyl acetate in mice


Luciana Ximenes has completed her PhD at the age of 31 years from Federal University of Ceara. She is a Professor of General Pathology at the Unichristus University Center in Fortaleza, Ceara, Brazil. He has published more than 10 papers in reputed journals and has been serving as an editorial board member of repute. Her research on depression with citronellyl acetate received an honorable mention at the Symposium on Medicinal Plants in 2012.


The citronellyl acetate is a monoterpene present in the essential oil of various plants with citronella. Studies have shown its activity as anti-inflammatory, antimicrobial substance analgesic, antioxidant, and being their biggest use in veterinary as insect repellent.The present study investigated the antidepressant activity in mice in the experimental tests the forced swimming and tail suspension test as well as the involvement of the monoaminergic system in these effects. Citronellyl acetate reduced the immobility time in the forced swimming test and tail suspension test, at doses of 50 and 100 mg/kg, p.o. The anti-immobility effect of citronellyl acetate (50 and 100 mg / kg) was reversed by pretreatment with PCPA 100 mg/kg i.p. (inhibitor of serotonin synthesis), Prazosin 1 mg / kg, i.p. (α-1 adrenoceptor antagonist), Yohimbine 1 mg / kg, i.p. (α-2 adrenergic receptor antagonist), SCH233390, 15 mg / kg, s.c. (D1 dopamine antagonist) sulpiride 50 mg / kg, i.p. (dopamine D2 antagonist). The analysis of the levels of monoamines showed an increase in the levels of monoamines (NA, DA and 5-HT) at a dose of 100 mg/kg of citronellyl acetate and the dose of 50 mg/kg increased levels of NA in striatum of mice. Thus, the study suggests that the anti-immobility effect of citronelila acetate in the forced swim test is related to its action on adrenergic, dopaminergic and serotonergic receptors, which was evidenced by an increase in the levels of monoamines in the brain, suggesting a possible antidepressant effect of this substance.