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Biography

Marco Antônio Peliky Fontes has completed his PhD at the age of 32 years from Federal University of Minas (UFMG), Brazil and Post Doctoral studies from University of Sydney, Australia. He is Associate Professor in the Dept. of Physiology and Biophysics at the UFMG. He has published more than 50 papers in reputed Physiology and Neuroscience journals. Member of the American Physiological Society and INCT Nanobiofar / Brazil. The central area of his research is Cardiovascular Neuroscience with focus in circuits involved in the cardiovascular response to emotional stress and the central contribution of peptides for cardiovascular control.

Abstract

Maintenance of homeostasis depends upon mechanisms controlling autonomic output. Sympathetic output depends on neuronal activity from different brain regions. Central requirement for changes in sympathetic output must be adjusted to the input signals from neural and humoral factors for an optimum cardiovascular performance. Consequently, abnormal inputs to one or more brain regions involved in the sympathetic control can lead to cardiovascular disease. Contributing factors may involve; abnormal feedforward and feedback mechanisms and altered humoral factors including angiotensinergic and leptinergic inputs. The dorsomedial hypothalamus is a key central region for the control of sympathetic outflow to the cardiovascular system. Recently, the descending sympathetic pathways from dorsomedial hypothalamus have been revealed. Reviewing the descending pathways from dorsomedial hypothalamus we discuss the interactions between mechanisms controlling the sympathetic output to the cardiovascular system and the possible implications in cardiovascular disease. Support: CNPq, FAPEMIG, CAPES.