University of Georgia, USA
Dr. Ming Zhang received the Ph.D. degree (Summa Cum Laude) from University of Gottingen, Germany. She has over a decade experience in infectious diseases, in particular targeting vaccine designs for HIV and influenza viruses. She is an Assistant Professor of Epidemiology at University of Georgia, USA, and leads an interdisciplinary research group towards understanding pathogen diversity and mechanisms for vaccine design purposes. She is also keen in educating the next generation of critical thinkers and innovators in infectious diseases.
N-linked glycosylation is a posttranslational modification that has significantly contributed to the rapid evolution of HIV-1. In particular, enrichment of N-linked glycosylation sites can be found within Envelope variable loops, regions that play an essential role in HIV pathogenesis and immunogenicity. In this presentation, I will describe some strategies we learned through though studies of HIV N-linked glycosylation, on both individual and population aspects, that can be implemented in virus vaccine designs, including for influenza prevention purposes.