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Moses SS Chow

Moses SS Chow

Western University of Health Sciences, USA

Title: Symposium:

Biography

Moses S S Chow graduated from University of California and currently is Professor of Pharmacy Practice and Director of Center for Advancement of Drug Research and Evaluation (CADRE) at the College of Pharmacy, Western University of Health Sciences, Pomona, California. His previous academic appointments included Professor, University of Connecticut School of Pharmacy and Director, Chinese University of Hong Kong. He has supervised/co-supervised over 40 Masters and PhD degree students and Post-doctoral fellows. He has published as author/co-author over 300 hundred articles, book chapters, monographs in pharmacokinetic studies, translational research and development of new drugs, including Chinese medicine. He has served as a consultant to NIH and USPs as well as visiting Professor to a number of Pharmacy Schools in Asia. He has served as Board member and Secretary of the American College of Clinical Pharmacology, President of American Chinese Pharmaceutical Association and Founding President and Board member of Asian Association of Schools of Pharmacy (AASP)

Abstract

Development of treatment strategies for resistant cancer with Chinese medicine, and prostate cancer as an example. Despite the availability of many potent anticancer drugs that can target cancer cells, great majority will acquired resistance during use, thus rendering treatment ineffective. It is well known that multiple cellular mechanisms of resistance can occur, such as decrease drug uptake, alteration of metabolism, increase efflux, modification of target, enhanced DNA repair, inactivation of apoptotic proteins and in activation of anti-apoptotic proteins. Treatment strategy of overcoming one specific mechanism of resistance at a time by the use of single compounds, e.g. inhibitors of Pgp responsible of anticancer drug efflux, has not been proven effective clinically. The reason is likely due to co-expression of other mechanisms of resistance. Thus a strategy of using herbs that contain multiple active components may be able to more effectively overcome chemo resistance by targeting multiple mechanisms. Specific examples of herbal extracts that can induce chemo sensitizing effect of the anticancer drug in resistant prostate cancer cells will be presented, based on in vitro and in vivo (xenograft model) experiments