Muhammad Irfanullah Siddiqui
Umm Al Qura University Al Abidia,KSA
Dr. Muhammad Irfanullah Siddiqui, Medicine Doctor (FCPS.-Community Medicine), now is Full Professor of Community Medicine and Public Health, Faculty of Medicine, Umm Al-Qura University. He is also head of the Research and Evaluation unit, Students Mentoring Program. He served at very important and highly academic position including Chairman of Department of Community Medicine, Baqai Medical University, Chairman, Department of Community Health Sciences, Hamdard University, Vice Principal Bahria University and Dean Faculty of Health Sciences, Baqai University. He is Chief Editor of famous book of Community Medicine and Public Health. Dr. Siddiqui is editor of many reputed journals as well as reviewers of journals of academic excellence. He is MBBS graduate of Dow Medical College and did his MPH, MCPS, FCPS and MPhil in the field of Community Medicine and earned various awards in the field of education. He is visiting professor Karachi University, Aga Khan University, Ziauddin University, Dow University of Health Sciences, Institute of Business Management and many other institute of international repute. He was invited by Oxford Brooks University, England to deliver a talk on Primary Health Care to its Faculty and postgraduate students. He has conducted more than 200 research methodology workshops at national and international level. Currently he is working on various funded projects of public health importance.
Objective: This parallel, randomized, double blind clinical trial was designed to compare allopathic drugs MDF (a combination of metronidazole + diloxanide furoate) with Endemali (herbal product) for therapeutic cure rate and side effects in order to find out the most suitable drug for this killer disease.
Methodology: This double blind randomized clinical trial was conducted in two areas of Karachi, Pakistan after approval from ethical committee of Hamdard University. All those confirmed for E. histolytica were included in the study. One hundred and seventy one patients selected for study randomly allocated to two arms of 86 and 85 for allopathic and herbal treatment respectively. However 78 in allopathic and 75 in herbal group completed the study. Main outcome variable was treatment success or failure. Secondary outcome measures included side effects, and association with age and sex.
Results: No significant difference was observed in the socio economic and demographic variables at the baseline. No significant difference was found between the cure rate of MDF and Endemali; hence both drugs were equally effective in treating amoebiasis. Significant differences were reported for the side effects observed among the two groups and the price. The failure rate for the two drugs was 28.7%.
Conclusion: It is concluded that both Endemali and MDF are equally effective in treating amoebiasis. However Endemali has fewer side effects than MDF. New drugs need to be researched for the treatment of Entamoeba histolytica because of high failure rate of the two drugs against this killer organism.