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Ning Cheng

Lanzhou University School of Public Health, Lanzhou,China

Title: Relationships among HBV infection and Gallbladder Disease and Diabetes Mellitus in Jinchang Cohort

Biography

Abstract

Statement of the Problem: To confirm high-risk population of cholecystitis and gallstone by calculating the prevalence and incidence of cholecystitis and gallstone in Jinchang cohort, and to reveal the relationship between hepatitis B virus (HBV) infection and cholecystitis gallstones, cholecystitis gallstones and diabetes mellitus (DM), in order to provide science basis for prevention and treatment of related diseases deeply in Jinchang cohort. Methodology & Theoretical Orientation: Populations in baseline and follow-up were selected as subjects for this study. Through descriptive study, we study the prevalence and incidence of cholecystitis and gallstone. Logistic and Cox regression were used to analyze the effects of different HBV infection status on cholecystitis and gallstone and different state of cholecystitis gallstone on DM by estimating the odds ratio (OR), hazard ratio (HR) and 95% confidence interval (95% CI), based on Jinchang cohort. Conclusion & Significance: The prevalence of cholecystitis in the Jinchang cohort was 10.20% overall, 13.40% in females, and 8.17% in males. The incidence of cholecystitis in the Jinchang cohort was 6.32% overall, 8.50% in females, and 5.50% in males. Compared with the non-infection HBV, HBV infection replication would increase the risk of cholecystitis, the OR (95%CI) were 1.27(1.11-1.46) overall, 1.40(1.16-1.67) in males. Compared with the control group, HBV carriers would increase the risk of incidence of gallstone and the HR (95%CI) was 1.30(1.07-1.57) in males. Compared with non-infection HBV, HBV infection replication would also increase the risk of incidence of cholecystitis and the HR (95%CI) were 1.54(1.26-1.87) overall, 1.81(1.41-2.32) in males. Compared with no gallstones group, gallstones also would increase the risk of incidence of DM. The HR (95%CI) were 1.46(1.22-1.76) in males, 2.81(2.25-3.51) in females, 1.83(1.59-2.10) overall.