Oluseyi Adeboye Akinloye
Federal University of Agriculture, Nigeria
Akinloye graduated from the Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria in 1991 with a First – Class Honors Division. He had Master of Science (M.Sc) in Biochemistry from the same University in 1997. He obtained a Doctor of Philosophy (Ph.D) in Biochemistry in January 2008 from the Federal University of Agriculture, Abeokuta. He is actively involved in the teaching and supervision of Biochemistry students at both undergraduate and postgraduate levels and also carrying out researches with bias in the area of Phytomedicine/Enzymology.
Akinloye has been an External Examiner (undergraduate and Postgraduate) in many Universities both within and outside Nigeria. He has held both academic and administrative leadership positions at the Federal University of Agriculture, Abeokuta, coupled with being academic resource person to some neighboring Universities. He attended several conferences within and outside Nigeria. He has published over seventy (70) scientific articles in reputable journals and many refereed conference proceedings. He is presently a Professor of Biochemistry and Phytomedicine, as well as the Dean, College of Biosciences, at the Federal University of Agriculture, Abeokuta.
Non-steroidal anti-inflammatory drugs (NSAIDs) competitively inhibit cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandins (PGs). In addition to the outstanding anti-inflammatory potential of the NSAIDs, the associated side effects of the current NSAIDs have limited their therapeutic benefits. The therapeutic mechanism of action of NSAIDs is through the inhibition of COX-2 and COX-1, however, side effects of NSAIDs arise from the inhibition of COX-1. Hence, the need to search for novel compounds (phytochemicals) that can selectively inhibit COX-2. In the present study, Virtual High Throughput Screening techniques were employed to screen eight hundred and fifty (850) phyochemiclals from seventeen medicinal plants, the lead phytochemicals (Citrostadienol from Nicotiana tabacum and Eriodictyol from Sorghum bicolor, with binding energies of -10.9 kcal/mol and -11.1 kcal/mol respectively) that selectively inhibit COX-2 were selected. The pharmacological kinetic analyses of the lead phytochemicals were determined. Moreover, Citrostadienol and Eriodictyol down-regulated the expressions of pro-anti-inflammatory cytokines genes (TNF-α, IL-6, COX-2 and CRP) in HCl/ethanol induced inflammation in male Wistar rats. In-vivo biochemical assays carried out also give credence to the anti-inflammatory potentials of the lead compounds.