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Paulo R Z Antas

Oswaldo Cruz Institute-Fiocruz, Brazil

Title: Human neonates display altered ex vivo monokine production related to healthy adults

Biography

Paulo R Z Antas has completed his PhD from Fiocruz and Post-doctoral studies from Vanderbilt University Medical Center. He is the Vice-Head of Clinical Immunology Laboratory, Oswaldo Cruz Institute-Fiocruz, a public health organization in Brazil. He has published more than 30 papers in reputed journals and has been serving as an Editorial Board Member of repute.

Abstract

The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts towards the production of pro-inflammatory cytokines. In this study, we employed an array system to detect 9 pro- and anti-inflammatory cytokines and performed ELISA for 6 other cytokines. We then compared the immune response profiling in umbilical cord blood (UV) plasma samples with circulating levels in otherwise healthy donors (HD). Concentrations of ex vivo monokine levels, such as interleukins (IL)-18, IL-23 and IL-27, were profoundly reduced in the UV in relation to the HD group (p-values of 0.003, 0.009 and <0.0001, respectively). Conversely, UV-plasmatic TGF-1 levels displayed marked enhancement (p-value=0.005) in relation to HD. Several factors may be implicated in these neonatal alterations and additional characterization of a broader cytokine panel is warranted to reveal other possible candidates.

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