Chiang Mai University, Thailand
Prachya Kongtawelert has completed his PhD from Sydney University since 1992. He is currently working as Associate Professor in Department of Biochemistry. He is interested in researches concerning about pathogenesis of osteoarthritis, rheumatoid arthritis, including diagnosis and treatment. Further, he has developed the formulation for dietary supplement products based on the active ingredient of sesamin, which is a natural compound from sesame.
Sesame has been used as food over 4,000 years. It contains very high value of nutritional compounds. One of them is sesamin, which is the most containing of lignan in sesame. There are many research papers concerning about its pharmacological activities. This leading to the research, and development, and apply this natural compound, sesamin, for widely uses as functional foods and cosmetics. It has been studied in our laboratorie as anti-cartilage degradation (as anti-osteoarthritis and anti-rheumatoid arthrisits) by inhibition of the Inteleukin-1 Beta, which is the most potent pro-inflammatoray cytokine, throgh NFkB and NAPK sinalling pathway in human chondrocyte culture. Sesamin shows the chodroprotective effects in cartilage explant culture and papain induced cartilage degradation in rat model. We are also studied anti-osteoporosis as enhancing the mineralisation, and stimulating osteoblast functions by up-regulating Type-II Collagen, alkaline phosphatase, and bone morphogenetic protein-2 (BMP-2). The osteoclastogenesis was inhibited by sesamin. Furthermore, the neuro-protective effect on the LPS-induced neuronal cell (PC12) development has been studied. Finally, the pathway of commercialization for development of simple and innovative dietary supplement of healthy products from sesamin with other natural resources, such as black rice bran and pre-cooked rice have been succesfully formulated and sold in several countries, especially in Southeast Asian.