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Biography

Dr. Prakash.M.M.S Kinthada Professor in the Department Of Chemistry at Sri Vidyanikethan Engineering College, Jawahar Lal Technological University, Anantapur, A Rangam Peta, Tirupathi, India. Earlier He was an Associate Professor in Chemistry, GIT, Gitam University, Visakhapatnam, India. He has recently returned from USA, where he was a NIH visiting fellow at Karmonas Cancer Research Institute, Wayne State University School of Medicine. Earlier he was a Royal Society Visiting Scientist in the Inorganic chemistry laboratories at the University of Oxford, UK working on" Transition metal complexes as Anticancer Drugs". Earlier He was a visiting fellow at the Department of Chemical Engineering and Applied Chemistry at Aston University, Birmingham. Prior was to the Nehru Centenary British Council Fellow in the organometallic laboratories at Imperial college of Science, Technology and Medicine, London, UK. Prior to the CSIR Research associate in the organometallic laboratories, Department of chemistry, Indian Institute of Technology, Newdelhi, India. I have published all his research in high impact international journals and Presented paper sin International Conferences including American Chemical society Conferences. He published 33 International publications and 31 international conference presentations including American Chemical Society conferences.

Abstract

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc.