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Rashmi Rana

Rashmi Rana

Sir Ganga Ram Hospital, India

Title: Effect of phthalates on reproductive biomarkers of infertile male

Biography

Dr. Rashmi Rana joined Department of Research, Sir Gangaram Hospital, New Delhi, India as Scientist in Aug 2017 and she did his master in Biomedical Sciences and PhD, Biochemistry from AIIMS, New Delhi, India. She is recently working on Medical Toxicology as toxicology research is primarily to be concerned with three aspects of toxicology: adverse effects of therapeutic agents, acute intoxications, and chronic poisoning/environmental toxicology. The adverse effects of environmental toxicant should be considered along with the Toxicology of individual pollutant or groups of environmental pollutant. She has published 7 international research papers and 1 national and she was elected member of many societies. She is recipient of Three Best Oral presentations award and two Best Poster award, and also awarded travel student award winner of Society of Toxicology PPTOXII conference held in Miami FL, U.S.A, Dec 2008, awarded student winner of air pollution and health conference held in San Diego, California, U.S.A, March 2010.

 

Abstract

Phthalates are used in personal and consumer products, food packaging materials, and polyvinyl chloride plastics and have been measured in the majority of the general population of the India. Consistent experimental evidence shows that some phthalates are developmental and reproductive toxicants in animals. This study explored the association between environmental levels of phthalates and altered reproductive hormone levels in infertile adult male.

Blood and urine samples were collected from 150 infertile patients & 75 fertile volunteers recruited through Department of Urology, Safdarjung Hospital, New Delhi. Selected phthalates & their metabolites were measured in serum and urine samples by GC-M S& UPLC using NIOSH / OSHA detailed protocol. Linear regression models explored the relationship between specific gravity-adjusted urinary phthalate monoester concentrations and serum levels of reproductive hormones, including Estradiol, Testosterone, AP, LD, GGT and hydroxysteroid dehydrogenase. Although we found significant correlation between several phthalate (DICHP, DMOP, DEHP, BEHIP, DBP and DDIP) compounds and mean ranks of testosterone & estradiol in subject, indicating that steroid hormones were associated with phthalates in Indian population. Thus phthalates and their metabolites might be independent risk factors for male infertility.