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Rong-Jie Chein

Academia Sinica, Taiwan

Title: Chiral tetrahydrothiophene ligands in asymmetric catalysis

Biography

Rong-Jie Chein has completed his PhD from National Chiao Tung University and Postdoc from Harvard University. His field of research includes: Development of new synthetic strategies and methods, Total synthesis and the study of the chemistry and biology of natural products and designed molecules, Drug discovery.

Abstract

Chiral sulfur ligands are becoming a versatile tool in organic chemistry due to the blossomed development achieved in the past years. This presentation describes an expeditious and efficient preparation of enantiopure (thiolan-2-yl)diarylmethanols and the applications of their derivatives to the catalytic and asymmetric Corey-Chaykovsky epoxidation, the imino Corey-Chaykovsky aziridination, the Corey-Chaykovsky cyclopropanation, as well as the first oxathiaborenium catalyzed asymmetric Diels-Alder reaction.