Rong-Jie Chein

Academia Sinica, Taiwan

Title: Chiral tetrahydrothiophene ligands in asymmetric catalysis


Rong-Jie Chein has completed his PhD from National Chiao Tung University and Postdoc from Harvard University. His field of research includes: Development of new synthetic strategies and methods, Total synthesis and the study of the chemistry and biology of natural products and designed molecules, Drug discovery.


Chiral sulfur ligands are becoming a versatile tool in organic chemistry due to the blossomed development achieved in the past years. This presentation describes an expeditious and efficient preparation of enantiopure (thiolan-2-yl)diarylmethanols and the applications of their derivatives to the catalytic and asymmetric Corey-Chaykovsky epoxidation, the imino Corey-Chaykovsky aziridination, the Corey-Chaykovsky cyclopropanation, as well as the first oxathiaborenium catalyzed asymmetric Diels-Alder reaction.