Sameeh A. Mansour
National Research Centre, Egypt
Professor Mansour is the Former Head of Pesticide Chemistry Department, National Research Centre (NRC), Cairo, Egypt, and the Founder of "Environmental Toxicology Research Area". Currently, he is the President-in- Charge of the Egyptian Society of Toxicology (EST), the Official Representative of Egypt at the International Union of Toxicology (IUTOX), the Chairman of the National Committee of Toxicology (NCT), Academy of Scientific Research & Technology (ASRT), and Member of the Directory Board of the National Poison Control Center, Faculty of Medicine, Cairo University. Professor Mansour published more than 150 papers in scientific journals and twelve book chapters published by well-known publishing companies.
Exposure to pesticides at certain developmental stages of life can result in irreversible damage to organ structure and function. Of particular concern is the effect of exposure during the reproductive cycle, from preconception to breast feeding. Exposure of infants and children to neurotoxin compounds at levels believed to be safe for adults could result in permanent loss of brain function when it occurs during prenatal and early childhood periods of brain development. In this respect, we will introduce some toxicological effects of pesticide exposure at very low doses during gestation and lactation periods and the extended hazard to the offspring using mouse dams and their pups as test model organisms. The selected pesticides include a triazine herbicide (atrazine; ATZ), a chlorinated hydrocarbon compound (endosulfan; END) and an organophosphorus insecticide (chlorpyrifos; CPF), as well as their tertiary mixture. The role of vitamin E (α-tocopherol) to alleviate the toxic effects will be highlighted. In light of the results of the present study, it can deduce that exposure of adult female mice to contaminated food with any of the tested insecticides at their acceptable daily intake (ADI) can induce hepatic and renal oxidative stress and histopathological effects. Since mouse pups from the exposed dams during gestation and lactation periods depended only on breast feeding, the findings of the present investigation reveal that toxic effects of the tested pesticides , as well as ameliorative effect of vitamin E, occurred to the mouse pups via placental and breast feeding transfer. -1HNMR-Metabonomic analyses supported these findings.