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Biography

Shayan F Lahiji has completed his BS and MS from Yonsei University (South Korea) and is currently doing his PhD at the same university. Because of his outstanding contribution to science and new novel delivery systems, he has been awarded in different fields of science for “The best poster presenter” from 3rd world biotechnology conference, “The best research award” from Yonsei University and “The best academic poster” from BK21 PLUS Research Symposium and more. He has published papers in reputed journals such as “Scientific Reports” from Nature Publishing Group and “Biomaterials” from Elsevier.

Abstract

Transdermal drug delivery is regarded as an important route with high potential for drug delivery to overcome limitations of oral delivery and hypodermic injections. Among various delivery methods available, microneedles have gained interest due to their ability in delivering drugs with a high efficacy compared with topical application. Microneedles are referred to microscopic needles that are capable of delivering pharmaceutical compounds, proteins and even cosmetics into the skin in a minimally invasive manner. There are three main categories of microneedles; hollow, solid and dissolving. Dissolving microneedles are polymeric structures fabricated over a patch that encapsulate drug and deliver it into skin upon application. However, due to stiffness properties of skin, only small portion of microneedles get inserted into skin and the rest remains on the patch. Therefore, we developed a patch-less dissolving microneedle delivery system which delivers microneedles into skin through micro-pillar structures without causing pain in less than a second. We tested this sytem using insulin on diabetic mice and results showed that our micropillar based delivery system was capable of delivering insulin with approximately 60% higher efficacy than microneedles fabricated over patch and at a similar rate as hypodermic injection. Therefore, we believe that this system have a high potential to treat people suffering from diabetics in a minimally invasive manner without the need of hypodermic injection.

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