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Subhash C. Pandey

Subhash C. Pandey

University of Illinois at Chicago, USA

Title: Molecular and epigenetic basis of alcoholism

Biography

Subhash C Pandey received his PhD in 1987 from the Pharmacology division of the Central Drug Research Institute in Lucknow, India and then received his Postdoctoral training in neuropsychopharmacology in the Department of Psychiatry, University of Illinois at Chicago. He is currently a Professor of Psychiatry, Anatomy and Cell Biology and the Director of Neuroscience Alcoholism Research at the University of Illinois at Chicago. He also holds a position as a VA Career Scientist at the Jesse Brown VA Medical Center, Chicago. He received Bowles Lectureship from the Alcohol Research Center located at University of North Carolina, Chapel Hill in 2010 and 6th SN Pradhan Lectureship from the Department of Pharmacology, Howard University, Washington DC in 2011 and distinguished scientist award in 2014 from the association of scientists of Indian origin in America for his outstanding contributions in the field of alcoholism research. He is serving as a Field Editor of Alcoholism: Clinical and Experimental Research Journal since 2011.

Abstract

Alcohol misuse disorders are highly prevalent with as yet not fully elucidated biological underpinnings. Epigenetic mechanisms, such as histone modifications and DNA methylation, appear to be involved in changes in gene expression and synaptic plasticity associated with alcoholism. Furthermore, signaling mechanisms that regulate synaptic functions also have been shown to mediate alcohol-related behaviors. This symposium will provide a platform to bring together researchers studying the abnormal epigenetic and neuronal signaling mechanisms thought to contribute to alcoholism. A comprehensive summary of progress in these fields and overview of findings related to ethanol-induced biochemical modifications occurring in the brain will be presented. The findings from these presentations will help us identify novel epigenetic and signaling targets that can be used to develop future pharmacotherapy for alcoholism.