Ege University, Turkey
Sumru Savas is an Internal Medicine Specialist since 1999, Graduate of European Academy for Medicine of Ageing (2015). She is currently a PhD student in Elderly Health-Gerontology (From 2011) at Ege University Health Sciences Institute. She is an Internist and Lecturer at Geriatrics Section of Internal Medicine Department.
Lipoprotein associated phospholipase A2 (Lp-PLA2) is a reported risk factor for dementia. However, the relationship between Alzheimer’s disease (AD) and Lp-PLA2 is still debatable and to the best of our knowledge, no study has evaluated the associations between levels of Lp-PLA2, proinflammatory cytokines and neopterin in AD. In total, 59 patients with AD and 38 non-demented individuals were included in the case control study. Fasting serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin and Lp-PLA2 were determined using ELISA. The associations between AD and each of the variables were analyzed by logistic regression. The median Lp-PLA2 levels in AD and controls were similar (P=0.29, not significant). Median serum neopterin and IL-6 levels were significantly higher in patients with AD than in controls (P=0.0001 and P=0.03, respectively). In regression analyses, median neopterin levels, a lower level of education and female gender were significantly associated with AD when compared with controls (OR, 31.44, 95% CI 3.59-275.28, P=0.002; OR, 4.35, 95% CI 1.13-16.61, P=0.032; OR, 7.25, 95% CI 1.88-28.00, P=0.004, respectively). In contrast to previous evidence suggesting its role in dementia and AD, Lp-PLA2 enzyme levels were higher in the controls and no relationship between Lp-PLA2 and either proinflammatory cytokines or neopterin was identified in AD. Elevated neopterin levels may be considered inflammatory markers of AD.
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