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Biography

Tian Hai-Yan has completed her PhD at the age of 27 years from China Pharmaceutical University and postdoctoral studies from Jinan University College of Pharmacy. Now, she is an associate professor of Jinan University. She has published more than 40 papers in reputed journals including Chemistry-A European Journal, Journal of Natural Products, etc. She has held two national funds and is the obtainer of the Special Support Young talent Plan of Guangdong Province, China.

Abstract

Toad venom, locally called ChanSu, is the secretion of the postauricular and skin glands of toads Bufo bufo gargarizans Cantor or B. Melanostictus Schneider, has been widely used as a traditional Chinese medicine in the treatment of superficial infection, odontalgia and skin cancer, and is also useful as a chemical weapon against the natural enemies of toads. During our system chemical investigation of ChanSu, three novel rearranged bufadienolides, bufogargarizins A-C (1-3) were isolated from the CH2Cl2 extraction of ChanSu. Their structures with absolute configurations were elucidated by spectroscopic analysis, single crystal X-ray diffraction, and computational calculations. Compounds 1, 2 and 3 had unprecedented 7/5/6/5/6, 5/7/6/5/6 and 6/7/6/5/6 ring systems, respectively, instead of the 6/6/6/5/6 skeleton presented in common bufadienolides. Our proposed biosynthetic pathways as well as the identification of the key intermediates supported that they were biosynthesized from the normal bufadienolides.

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