Medical University of Bialystok, Poland
Tomasz Kamiński graduated Medical University of Białystok (Poland) with a master degree in pharmacy and currently is a PhD student at international Interdisciplinary Doctoral Studies in English at Medical University of Bialystok and Hasselt University. Presently he is the principal investigator of two projects supported by Leading National Research Centre (The Centre for Innovative Research at Medical University of Bialystok) and the project supported by the Polish National Science Centre. All above-mentioned projects focus on searching connections between kidney diseases and hemostatic disorders. Furthermore, he has been granted with the award of Rector of Medical University of Białystok for outstanding scientific achievements.
Objectives: Patients with chronic kidney disease (CKD) are at higher risk of incidence of thromboembolic events. The effect of continuous loss of function of nephrons is a progressive accumulation of uremic toxins. Indoxyl sulfate (IS) is an aggressive uremic toxin exerting proinflammatory and prooxidative properties, which affects multiple signaling pathways.
Aim: We examined the association between indoxyl sulfate and activation of the coagulation system in predialysis patients with CKD.
Methods: Studies have been conducted on a group of 53 patients with CKD on conservative treatment and 18 healthy volunteers. For the determination of parameters of coagulation ELISA-immuno-enzymatic kits were used, whereas the IS levels were determined by HPLC. The hematological and biochemical parameters were assessed using standard laboratory methods.