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Vincent Gallicchio

Vincent Gallicchio

Clemson University, USA

Title: The use of metal ions in personalized medicine for human diseases

Biography

Vincent S Gallicchio is Professor of Biological Sciences, Public Health and Microbiology at Clemson University. He is the Vice President of the Trace Element Research Centers operating under UNESCO and the immediate Past-President of the International Federation of Biomedical Laboratory Science. He has authored more than 200 peer-reviewed scientifi c articles, book chapters and textbooks. He is the Inventor on eleven US and one international patent focused on drug delivery. He has received more than $22 million in research funding. In 2003 he was presented to her majesty Queen Elizabeth of England for his efforts promoting higher education opportunities for British students

Abstract

Trace elements possess important therapeutic properties. First, binding to specifi c macromolecules (enzymes, nucleic acids, etc.) they infl uence important chemical and biological processes; second, they interact amongst themselves synergistically to amplify their individual reactions. Metals have been used therapeutically for hundreds of years. Use of metals in the treatment of human diseases began with discoveries with gold used initially in patients with tuberculosis followed by rheumatoid arthritis. Gold identifi ed an immunological pathogenesis in the etiology of rheumatoid arthritis, thus metals may be effi cacious in other human conditions that are immunological in etiology. Th e antineoplastic potential of metals was further disseminated by the development of less toxic compounds such as platinum. Th ird, metals in human cancers have increased their therapeutic eff ectiveness and increased the diversity of cancers responding to these treatments. Fourth, lithium use in clinical medicine revolutionized treating psychiatric mood disorders. Central to the biological action of lithium is its ability to infl uence brain and central nervous system chemistry, thereby providing spectacular results in the treatment of aff ective and other psychiatric mood disorders, in particular, suicide prevention. Discoveries defi ning alternative non‐psychiatric clinical use of lithium continue to intrigue clinical medicine based upon a key discovery demonstrating lithium can eff ectively infl uence stem cells. Halo-therapy is using salt compounds as initial and maintenance therapy of human respiratory ailments. Used by the Greeks and Romans, halo-therapy has existed for thousands of years. It is associated with the therapeutic eff ectiveness attributed to spas. Today, halo-therapy has gained resurgence with its use as personalized medicine in the treatment of human diseases