Neglected tropical parasitical diseases are major health problem in developing countries of the world and strongly affect almost exclusively poor population living in developing counties. Sudan is one of developing countries highly endemic with malaria (all known species were reported), schistosomiasis, leishmaniasis, trypanosomiasis, gastrointestinal protozoa and helminthes. Many of them spread by insect vectors, snails or contact with contaminated water or soil. Unfortunately there is serious lack of interest in the research and control of these diseases. Therefore Medicinal and Aromatic Plants Research Institute conducted comprehensive research to develop new drugs adapted to our country needs and to make them available at affordable prices for common people. The present paper will highlight the efforts of previously screened medicinal plants for their antiparasitical activities and our future prospect to develop new antiparasitical drug from Sudanese medicinal plants.