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Biography

Yan-Yeung Luk has completed his PhD at The University of Chicago, and postdoctoral studies from University of Wisconsin-Madison. He is the founder of LifeUnit LLC, a startup company focused on chemical control bacterial activities. He has published more than 30 papers in peer-reviewed journals and has been serving as a reviewer for NSF, and ACS journals. He is also a member on the scientific advisory broad of Orthobond INC.

Abstract

Bacterial appendages, pili protein, have been explored for developing vaccines against infectious diseases, but without an eventual success. Here, we present a chemical approach of controlling the newly discovered signaling events that initiated by ligand binding to pili proteins on bacterial surfaces. We first demonstrate that a specific class of molecules that control a wide range of pathogenic activities of Pseudomonas aeruginosa, and the characteristics of disrupting cell signaling of these activities, supporting the notion of a drug development. Second, we demonstrate the specific covalent coupling between a designed ligand molecule and the pili protein as a validation of the receptor protein identity. We will discuss the chemical structural space that validates a hydrocarbon-omic for controlling different species and different strains within a species of microbes.