Youmna Mohamed Sherief Abdel-Nabi
Alexandria University, Egypt
Youmna has completed her MsC at the age of 28 years from Alexandria University and a diploma in Proffesional Healthcare Management from The American University in Cairo. She is an ass. lecteurer of Oral Biology and Dental Morphology at the Faculty of Dentistry, Ahram Canadian University in Egypt. She has managed to publish one paper at the Alexandria Dental Journal, and an E-poster in the 29th Annual American Dentistry congress. She is a young dedicated researcher in the field of bone regenration.
Studies concerning healing of extraction sockets revealed that sockets are filled with new bone by as much as two thirds in 40 days and completely filled with new bone in 10 weeks. There have been many studies demonstrating the bone-promoting effect of simvastatin local application in animal models. Simvastatin is shown to increase bone volume, bone formation rate, and bone compressive strength. The use of statins for bone regeneration is a promising and growing area of research. Statin drugs are mainly used in the treatment of high cholesterol since the discovery in the 1970s. The molecules produced by Penicillium citrinum, called citrinin and compactin (mevastatin), are potent inhibitors of an important enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) in the cholesterol production pathway.The first experimental evidence in an animal model of the osteo-modulador effect of statins was reported by Mundy et al who demonstrated that treatment with simvastatin resulted in a significant increase (up to 2–3 times compared with controls) in the rates and bone formation markers, and that the effect of statins were comparable to that induced by treatment with bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor, which are known stimulants of bone metabolism. The aim of this study is to examine the influence of simvastatin on bone healing in extraction socket of first molar in rat mandibles, where the specimens will be processed for scanning electron microscopy, light microscopy and immunohistochemical detection of Vascular Endothelial Growth Factor and Fibronectin.