Youssef Ali Abou Hamin Neto

School of Pharmaceutical Science of Ribeirão Preto-USP, Brazil

Title: The relevance of the protease cleavage site in generation of bioactive peptides: In silico and in vitro approaches


Youssef Ali Abou Hamin Neto has completed his Master of Science from the Faculty of Pharmaceutical Sciences of Ribeirão Preto (2012) and graduate degree in Pharmacy from the Federal University of Alfenas (2009). He is currently pursuing PhD in Pharmaceutical Sciences at the concentration area of Natural and Synthetic Products under the guidance of Professor Dr. Hamilton Cabral, Faculty of Pharmaceutical Sciences of Ribeirão Preto of University of São Paulo.


Introduction: Proteases are biocatalysts that hydrolyze polypeptides into peptides and/or amino acids. Each enzyme has specificity to substrate and cleavage site, these characteristics influence the product sequence and consequently the potential application. The proteases have been used to obtain peptides from food proteins, these products can present biological activities such as antioxidant, antitumor, antimicrobial and anti hypertensive and currently the main source of peptides are milk proteins.