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Drug Repurposing or otherwise referred to as drug repositioning/ re-profiling/ therapeutic switching, is the process of testing adept pharmaceutical agents for hitherto unknown therapeutic implications. Though the idea behind this process is highly simple, its practical implications are multidimensional. The concept of drug repurposing relies on the fact that a single or combination of pharmaceutical agents does not always imply a particular physiological outcome. Ingestion of any bioactive agent elicits a plethora of biomolecular responses inside the body, some evidently prominent while others not so much. However, altering the concentration of the administered pharmaceutical formulations may lead to the manifestation of entirely different therapeutic responses i.e. the same drug can imply variable number of therapeutic roles. The most important advantage of drug repurposing and finding alternative therapeutic implications of already in use drugs is that, if successful the drug does not have to go through the extensively lengthy procedure of toxicological analyses and multilevel safety screening process. It can be directly released into the pharmaceutical industry for clinical application. This special issue will serve to propagate the concept, study, research and implementation of drug repurposing for the treatment of diseases. The issue will serve as to emphasise on drawing the attention of clinical researchers towards screening the therapeutic roles of the available drugs which they are not advertised for. The scope of the special issue includes: • Repurposed drugs for the treatment of cancer • Treating brain disorders and addiction with drug repurposing • Computational tools for studying drug repurposing • Reproducible drug repurposing • Computational chemistry • Structural and functional pharmacogenomics The journal invites original scientific manuscripts that showcase contemporary findings and clinical case studies that substantiate the clinical application of repurposed drugs for the treatment of acute and chronic diseases.