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Metabolomics refers to the study of the methods, processes and pathways that may either lead to the formation of metabolites or use them for carrying out physiological functions. Metabolomics also encompass the study of structure, function and biomedical implications of metabolites. According to the Metabolomics Society, “Metabolomics is the study of metabolic changes. It encompasses metabolomics, metabolite target analysis, metabolite profiling, metabolic fingerprinting, metabolic profiling, and metabonomics”. The study of metabolomics can be understood as an analogous pathway of genomics. While genomics refers to the study of the entire set of genetic material of an organism, metabolomics involves the study of the entire set of metabolites present in an organism in a given set of conditions. Metabolomic analyses provide the functional readout of the physiological conditions of a person based on his/her genetic blueprint, protein expression and modification strategies, and the external environment. Ever since scientists conceptualized metabolomics as a scientific discipline, medical researchers have been trying to imply it in development of diagnostic and therapeutic procedures that may be applied for the detection and treatment of acute and chronic diseases. The multifaceted application of metabolomics is attributed to the facts that while the genomic constitution of an organism remains same throughout life, the metabolic components vary with changes in the external and internal factors of the body. In other words, influence of external biotic and abiotic factors like temperature and microbial exposure; and internal factors like aging or diseases like cancer and diabetes, can change the levels of metabolites formed. Hence they may be used as effective molecular biomarkers. Tracking and correlating these metabolic changes for biomedical applications opens new dimensions in the process of treatment and management of diseases. Furthermore, real time point of care application of metabolic biomarkers may help in the process of development of personalized prognostic, diagnostic, and treatment approaches. Application of metabolomics in personalized medicine can also help in monitoring disease progression, clinical efficacy of specific treatment methods, predisposition to drug-related side effects, and potential relapse. This special issue will publish latest research developments in the various aspects of the following interdisciplinary fields: • Metabolite profiling • Metabonomics and NMR • Advanced chromatographic and spectroscopic methods in study of metabolomics • Environmental metabolomics • Personalized medicine • Cancer metabolomics • Drug development The special issue also aims to publish novel research findings that highlight the role of metabolomics in the process of development of personalized medicines. The journal invites original manuscripts that are based on conceptual and applicatory aspects of metabolomics, with special reference to the process of development of personalized medicines.