The purpose of antibiotic prophylaxis in surgical procedures is not to sterilize tissues but to reduce the colonization pressure of microorganisms introduced at the time of operation to a level that the patients immune system is able to overcome. Prophylaxis does not prevent infection caused by postoperative contamination
Surgery in gynecology oncology includes radical extensive abdominal and pelvic procedures with risk of postoperative infection. An important aspect in gynecology oncology and in surgery in general is to reduce the rate of surgical site infections (SSIs) which occur for 40 % of all noso comial infections in surgical patients and occur in up to 20 % of patients undergoing abdominal surgery; there is a twofold increase in mortality in surgical patients with SSIs. It is widely accepted that preoperative that factors which increase preoperative infection rate in women undergoing radical pelvic surgery are associated with elongation of duration of surgery, patients performance status, anemia, nutritional status, history of post surgical infections, metabolic diseases, presence of malignancy, post irradiation and post chemotherapy status, obesity etc
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Panagiotis Peitsidis: Antibiotic Prophylaxis in Gynecology, Oncology and Surgical Procedures a Brief up-to Date
Last date updated on June, 2014