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Craniopharyngioma is a type of brain tumor derived from pituitary gland embryonic tissue that occurs most commonly in children but also in men and women in their 50s and 60s. People may present with bitemporal inferior quadrantanopia leading to bitemporal hemianopia, as the tumor may compress the optic chiasm. Craniopharyngiomas are typically very slow growing tumors. They arise from the cells along the pituitary stalk, specifically from nests of odontogenic (tooth-forming) epithelium within the suprasellar/diencephalic region and, therefore, contain deposits of calcium, which are evident on an x-ray. Balance disorder, Dry skin, Fatigue, Fever, Headache, Hypersomnia, Lethargy, Myxedema, Nausea etc. include is symptoms.
The annual incidence is 0.5-2.0 cases/million/year and approximately 60 % of Craniopharyngiomas are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. The standardised overall mortality rate varies 2.88-9.28 in cohort studies.
Treatment generally consists of subfrontal or transsphenoidal excision. Surgery using the transsphenoidal route is often performed by a joint team of ENT and neurosurgeons. Because of the location of the craniopharyngioma near the brain and skullbase, a surgical navigation system might be used to verify the position of surgical tools during the operation. Additional radiotherapy is also used if total removal is not possible.
The ongoing researches in Sweden on craniopharyngioma include: Hypothalamic involvement predicts cognitive performance and psychosocial health in long-term survivors of childhood craniopharyngioma, Primary treatment regimen and diabetes insipidus as predictors of health outcomes in adults with childhood-onset craniopharyngioma.
