Osteosarcomas are primary malignant tumors of bone that are characterized by the production of osteoid or immature bone by the malignant cells. Osteosarcomas are uncommon tumors. Approximately 750 to 900 new cases are diagnosed each year of which 400 arise in children and adolescents younger than 20 years of age.
Despite their rarity, osteosarcomas are the most common primary malignancy of bone in children and adolescents, and the fifth most common malignancy among adolescents and young adults aged 15 to 19. Chemotherapy can successfully eradicate these deposits if initiated at a time when disease burden is low. As a result, all patients with osteosarcoma are treated with adjuvant chemotherapy, and most receive this treatment modality in the preoperative period.