The disease is most often seen in Asia, Europe, North America. In America and Europe, rat bite fever is usually due to S. moniliformus, while in Asia it is usually due to S. minus. Many cases of rat bite fever go undiagnosed as it is easily controlled by antibiotic therapy. Rat bite fever can be treated readily with antibiotics (penicillin and tetracyclin), but untreated S. moniliformis infections are estimated to be fatal. Doxycycline and erythromycin can be used as alternative form of treatment. People should be advsied to prevent contamination of water and food by rat excrement.