Sarcoidosis is a systemic disorder characterized by non-necrotizing granulomatous inflammation, with varying degrees of concomitant fibrosis. It predominantly affects the lungs, eyes, and skin. A transmissible cause has long been suspected based on epidemiologic studies, transmission via organ transplantation
Sarcoidosis is an enigmatic systemic granulomatous disease of unknown etiology.The symptoms of sarcoidosis can vary greatly, depending on which organs are involved. Most patients initially complain of a persistent dry cough, fatigue, and shortness of breath.
The use of registries of serial autopsy reports of a specific population is another method to report the occurrence of sarcoidosis. In 1964, HA¨gerstrand and Linell described 43 cases of sarcoidosis among 6,706 autopsies (i.e. 60% of the population who died) in 1957–1962 in Malmo¨ (Sweden), and calculated a prevalence of 640 per 100,000.