Typhoid fever, also known as enteric fever, is a potentially fatal multisystemic illness caused primarily by Salmonella enterica, subspecies enterica serovar typhi and, to a lesser extent, related serovars paratyphi A, B, and C. In the year 2006, 12 cases of Typhoid fever were reported in Sweden. The prevalence rate was 0.1%. Highest prevalence rate was reported in the years 1999 that is 1.2%.
The protean manifestations of typhoid fever make this disease a true diagnostic challenge. The classic presentation includes fever, malaise, diffuse abdominal pain, and constipation. Untreated, typhoid fever is a grueling illness that may progress to delirium, obtundation, intestinal hemorrhage, bowel perforation, and death within 1 month of onset. Survivors may be left with long-term or permanent neuropsychiatric complications. Researches happened on Comparative genomics study for identification of putative drug targets in Salmonella typhi Type 2.