Antiphospholipid syndrome occurs when immune system mistakenly attacks some of the normal proteins in r blood. Antiphospholipid syndrome can cause blood clots to form within arteries or veins. Antiphospholipid syndrome may cause blood clots to form in leg veins, a condition known as deep vein thrombosis (DVT).
The Euro-Phospholipid Group analyzed the prevalence of the most relevant clinical and immunological features in a cohort of 1000 APS npatients derived from 13 countries. A recent large multicenter study showed that β 2GPI-dependent aPL can be found in almost 10% of ng premenopausal women hospitalized for the first MI.
In antiphospholipid syndrome, body mistakenly produces antibodies against proteins that bind phospholipids, a type of fat present in blood that plays a key role in clotting (coagulation). Antibodies are specialized proteins that normally attack body invaders, such as viruses and bacteria. When antibodies attack phospholipid-binding proteins, blood may clot abnormally.