Castleman disease is a rare disorder that involves an overgrowth (proliferation) of cells in your body's disease-fighting network (lymphatic system). Also known as giant lymph node hyperplasia and angiofollicular lymph node hyperplasia, Castleman disease can occur in a localized (unicentric) or widespread (multicentric) form.
Fever. Night sweats. Fatigue and weakness. Loss of appetite. Unintended weight loss. Enlarged lymph nodes, usually around the neck, collarbone, underarm and groin areas. Enlarged liver or spleen.
During 212,042 person-years of follow-up, 521 patients were diagnosed with systemic NHL and 62 with primary brain lymphoma (PBL). The incidence rate of systemic NHL was 463 per 100,000 person-years not on cART and 205 per 100,000 person-years in treated patients, for a rate ratio of 0.44 (95% confidence interval [CI] 0.37 to 0.53). The corresponding incidence rates of PBL were 57 and 24 per 100,000 person-years (rate ratio 0.43; 95% CI 0.25 to 0.73).