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Membranous nephropathy is a kidney disorder that leads to changes and inflammation of the structures inside the kidney that help filter wastes and fluids. MCD is the most common primary glomerular disease in children.
Disease pathophysiology:
Membranous nephropathy is a disease with subepithelial deposits forming diffusely along the peripheral capillary loops, associated with extensive effacement of visceral epithelial cell foot processes and resultant heavy proteinuria and nephrotic syndrome. M2 Phospholipase A2 receptor (PLA2 R) has been recognized as the target antigen in Idiopathic membranous nephropathy (IMN).
Disease statistics:
Accounting for 70% to 90% of cases of nephrotic syndrome for those younger than 10 years, with the incidence peaking between ages 2 and 4 years.1 The prevalence declines with age, whereby it is responsible for only 10% to 20% of cases of nephrotic syndrome in adults. There appears to be a higher predominance in Asia compared with the United States and Europe, although no strong gender predominance exists.
Disease treatment:
The use of corticosteroid has not improved the course of renal disease and has actually contributed to the progression to the chronic active hepatitis. There is always the possibility that patients may have spontaneously seroconversion without antiviral treatment. Spontaneous clearance of HBV antigen is slow.
Major research on disease:
Thrombospondin type-1 domain-containing 7A—a new player in membranous nephropathy.MCD is the most common primary glomerular disease in children.
