Prostate cancer occurs when abnormal cells develop in the prostate. These abnormal cells can continue to multiply in an uncontrolled way and sometimes spread outside the prostate into nearby or distant parts of the body. Prostate cancer is a malignancy of one of the major male sex glands. Along with the testicles and the seminal vesicles, the prostate secretes the fluid that makes up semen.
Pathopysiology: Prostatic intraepithelial neoplasia (PIN) is the histologic entity widely considered to be the most likely precursor of invasive prostate cancer. Although not all patients with high-grade PIN (HGPIN) progress to develop invasive disease. It is characterized by cellular proliferation within pre-existing ducts and glands, with cytologic changes that mimic those of cancer. PIN is associated with progressive abnormalities of phenotype and genotype that are intermediate between normal prostatic epithelium and cancer. The recognition of the strong association of HGPIN and cancer has led many investigators to propose its use as an intermediate marker in chemoprevention studies.
Risk Factors: Factors that are most strongly linked to an increased chance of developing prostate cancer: Age: Prostate cancer is an age-dependent disease, which means the chance of developing it increases with age. The risk of getting prostate cancer by the age of 75 is 1 in 7 men. By the age of 85, this increases to 1 in 5.