Sclerosing mesenteritis is an uncommon idiopathic disorder characterised by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery.Tests and procedures used to diagnose sclerosing mesenteritis include. 1. Physical exam: sclerosing mesenteritis often forms a mass in upper abdomen that can be felt during a physical exam. 2. Imaging tests: Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography or magnetic resonance imaging. 3. Biopsy: Removing a sample of tissue for testing.
The disease includes three stages.
Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat.
Stage-2: mesenteric panniculitis, inflammatory reaction.
Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.
History of sclerosing mesenteritis is not well understood, because of the rarity of this condition. In a five-year follow-up report of 47 patients with mesenteric Sclerosing mesenteritis, 65 percent were alive, and in those who died, one-half of the deaths were due to malignancy (50 percent carcinoma, 50 percent lymphoma) In another series, 12 percent of patients developed malignancy, including lymphoma, carcinoid syndrome, lung adenocarcinoma, and mesothelioma. Fulminant cases of sclerosing mesenteritis have been reported and are largely due to complications of intestinal obstruction.