Transient global amnesia (TGA) has been a well-described phenomenon for more than 40 years. Clinically, it manifests with a paroxysmal, transient loss of memory function. Immediate recall ability is preserved, as is remote memory; however, patientsexperience striking loss of memory for recent events and an impaired ability to retain new information. In some cases, the degree of retrograde memory loss is mild. The precise pathophysiology of transient global amnesia is not clear.
On PET and DWI, blood flow to specific brain areas that involve memory appears to be disrupted transiently during TGA. This includes the thalamus and/or mesial temporal structures (in particular the amygdala and hippocampus). The incidence has been estimated 8.2 per 100,000 per annum. Medical Care Once transient global amnesia (TGA) is diagnosed, provide reassurance to the patient and schedule at least one follow-up visit with a neurologist.