Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles.
629.900 Swiss adults have diabetes, i.e., 11,3% of the total population. An additional 339.200 citizens (6.1% of the population) suffer from impaired glucose tolerance (pre diabetes). This situation will deteriorate in the future, with an estimated 726.500 adult citizens with diabetes in 2030.3.350 Swiss citizens die from diabetes every year. This means 9 citizens every day. Type 2 diabetes, accounting for 80-90% of all diabetes in Switzerland, decreases life expectancy by 5-10 years..
Type 2 Diabetes afflicts close to 250 million people in world today, 27 million in the United States alone. The world wide incidence of Type 2 Diabetes is increasing in epidemic proportions.one of three children born today, at some stage in their lives, will become Diabetic and develop disabling or fatal complications of the disease. The Clinical Research in Type 2 Diabetes program supports human studies across the lifespan aimed at understanding, preventing and treating type 2 diabetes (T2D).