Department of Radiation Oncology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Received date: April 29, 2013; Accepted date: May 20, 2013; Published date: May 22, 2013
Citation: Akhavan A (2013) The Broad Ligament Leiomyosarcoma Metastasis to the Abdominal Wall. J Nucl Med Radiat Ther S6:013 doi:10.4172/2155-9619.S6-013
Copyright: © 2013 Akhavan A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Nuclear Medicine & Radiation Therapy
Leiomyosarcoma of the broad ligament is a rare tumor and according to our knowledge only twenty cases have been reported in the English literature. Gardner et al. emphasize that, “these tumors occur on or in the broad ligament, but are completely separated from and in no way connected with either the uterus or the ovary” . On the other hand metastasis of leiomyosarcoma to the abdominal wall is very rare and there is no any report of leiomyosarcoma of broad ligament with more than 33 months fallow up and metastasis to the abdominal wall . In this paper an Iranian 60 year old lady with metastatic leiomyosarcoma of abdominal wall five years following to than resection of lieomyosarcoma of the broad ligament is presented. It seems that the tumor’s grade has worsened by time.metastatic tumor became worst with timing
An abdominopelvic and thoracic CT scanning was carried out which showed an oval shaped well defined soft tissue mass measuring 73 mm×44 mm just under the skin in the lower part of the abdomen attached to the rectus abdominis muscles exerting pressure on the contagious bowel loops (Figures 1a and 1b). Other parts of the abdomen and lungs were normal.
The pathologic differential diagnosis of leiomyosarcomas traditionally includes other sarcomas composed of fascicles of moderately differentiated spindle cells, such as fibrosarcoma and malignant peripheral nerve sheath tumor.
The patient was referred to the surgeon and her tumor was resected with negative margins. The tumor originated from rectus abdominis muscles. Pathological examination showed a cream-brownish colored lobulated mass composed of neoplastic cells with spindle shaped nuclei and slender cytoplasm arranged in fascicles and a herringbone pattern with more than 20 mitotic figures/10 high power fields.
Giant monstrous cells were also present (Figure 2). Immunohistochemical study showed positive staining for Alpha smooth muscle actin (Figure 3), Desmin and Vimentin and negative staining for CD117 (Figure 4). Diagnosis was metastatic high grade leiomyosarcoma.Repeated abdominal CT scanning did not show any residual disease. At least inferior part of the tumor was located in the previous radiation field and therefore we omitted radiation therapy, however because tumor was metastatic and high grade chemotherapy with Gemcitabine 900 mg/m2 on days 1 and 8 and Docetaxel 100 mg/m2 on day 8 was prescribed for four cycles.
Now nine months after completing of chemotherapy the patient is well. We will perform abdominopelvic CT scanning three months later.
The broad ligament is a peritoneal fold attaching the uterus, fallopian tubes, and ovaries to the pelvis. It is composed of a double-layered sheet of mesothelial cells. Between these two layers there is an extraperitoneal tissue referred to as the parametrium and consists of connective tissue, smooth muscles, nerves, and blood vessels . Tumors of the broad ligaments are rare. Leiomyoma is the most common solid tumor of the broad ligament [2,4]. Primary malignant tumors of the broad ligament are rare and among these rare cases however,leiomyosarcoma is more common. Other malignant tumors have been seen in/on the broad ligament and must be distinguished from leiomyosarcoma including gastrointestinal stromal tumors, endometrial stromal sarcoma, malignant fibrous histiocytoma, carcinosarcoma [2,4]. This tumor commonly occurs in postmenopausal women; however some cases were premenopausal [5,6]. The symptoms are nonspecific and in almost all cases a definitive diagnosis preoperatively is impossible [2,5-7].
One of the most important issues in the management of these tumors and predicting the patients’ prognosis is differentiation of leiomyosarcoma from leiomyoma and its variants.
The diagnosis of uterine LMS relies on the presence of three criteria: coagulative tumor cell necrosis,cytologicatypia and mitotic activity. Zaloudek and Hendrickson  proposed that presence ofcoagulative necrosis itself is enough for diagnosis of leiomyosarcoma. In the absence of cell necrosis the diagnosis of leiomyosarcoma needs diffuse moderate to severe cellular atypia and more than 10 mitosis/10 HPF [8,9]. Histological grading of soft tissue sarcomas and their effect on survival is a gray zone in these tumors. There are two major grading systems for grading of soft tissue sarcomas: the NCI (United States National Cancer Institute) system and the FNCLCC (French Fédératio Nationale des Centres de Lutte Contre le Cancer) system. The NCI system uses a combination of histological type, cellularity, pleomorphism and mitotic rate for attributing grade 1 or 3. The FNCLCC system is based on a score obtained by evaluating three parameters: tumor differentiation, mitotic rate (0-9, 10-19 and = 20 mitotic figures/10HPF) and the amount of tumor necrosis (<50% tumor necrosis and = 50% tumor necrosis). According to both of them leiomyosarcoma is classified into low, intermediate and high grade.
Lung ,liver and peritoneal cavity are the most common sites of metastasis.In this patient the metastatic lesion’s grade has increased gradually. Metastasis of leiomyosarcoma to the abdominal wall is very rare and was not reported in leiomyosarcoma of the broad ligament.
Controversies exist regarding the effectiveness of adjuvant therapy. Although radiation therapy improves local control, it does not mean any survival advantage for these patients. Chemotherapy in adjuvant setting did not show a survival benefit. Fixed-dose Gemcitabine (900 mg/m2 on day 1 and 8) combined with Docetaxel (100 mg/m2 on day 8) has been shown to achieve high objective response rates as the first line therapy in metastatic uterine leiomyosarcomas . From the twenty one previous reported cases only nine patients had received chemotherapy or radiotherapy or both and only for seven patients less than one year survival was reported.
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals