alexa The Cause of Preeclampsia | OMICS International
ISSN: 2157-7420
Journal of Health & Medical Informatics
Like us on:
Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

The Cause of Preeclampsia

Kazuo Maeda*

Department of Obstetrics and Gynecology, Tottori University Medical School, Yonago, Japan

*Corresponding Author:
Kazuo Maeda
Department of Obstetrics and Gynecology (Honorary Professor)
Tottori University Medical School, Yonago, Japan
E-mail: [email protected]

Received Date: October 14, 2013; Accepted Date: October 15, 2013; Published Date: October 19, 2013

Citation: Maeda K (2014) The Cause of Preeclampsia. J Health Med Informat 5:e111. doi: 10.4172/2157-7420.1000e111

Copyright: © 2014 Maeda K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Health & Medical Informatics

Introduction

The preeclampsia is a common maternal disorder in pregnancy, characterized by hypertension (pregnancy induced hypertension, PIH) and associates proteinuria in 20 or a later week of pregnancy, which is also accompanied by enlarged hydatidiform mole pregnancy, and disappears after the birth. The presence of the fetus was proposed as its cause, while a hydatidiform mole has no fetus. Trophoblasts were considered to be the cause, but very active trophoblasts did not cause preeclampsia in the choriocarcinoma, while low invasion of trophoblasts to the uterine spiral artery was considered as its cause. Immunological phenomenon between the mother and fetus was denied as its cause. Very many metabolic changes were proposed as its cause, but they were partial phenomenon of preeclampsia. One hundred or more theories were proposed, but a review article in 2010 concluded that the cause of preeclampsia was unknown.

Kurotsu [1] reported the presence of sympathetic and the parasympathetic centers in the hypothalamus of rabbit 1949, and electrically stimulated the sympathetic center, resulting the increase of rabbit’s blood pressure. The author of this article studied the electroencephalogram (EEG) of human eclampsia and preeclampsia in pregnancy, and tried to record deep hypothalamic EEG, where the sympathetic and parasympathetic centers of female non-pregnant rabbit were stimulated by using Kurotsu’s electrode [1]. A hole was drilled on the coronal suture, 1 mm apart from the midline, and inserted the bipolar electrode for 15 mm deep for the stimulation of sympathetic center with an induction coil and 1.5 V dry battery for 10 sec. The blood pressure was measured at the central artery of the rabbit’s ear before and after the electric stimulation, and urine was obtained inserting a thin catheter into rabbit’s bladder, before and after the stimulation. Stimulated rabbit was excited; blood pressure elevated and proteinuria appeared at the same time in 3 out of 4 experimental rabbits. The parasympathetic center was stimulated further 1 mm outside of sympathetic for 10 sec, where no blood pressure change and no proteinuria were noted. The location of electrode was confirmed by the coronal section of rabbit’s brain. In summary of experiments, electric stimulation of sympathetic center for 10 sec provoked hypertension, and at the same, proteinuria by stimulation of sympathetic center [1]. Human preeclampsia would be caused by the stimulation of sympathetic hypothalamic center, which would be continuously stimulated by the enlarging uterus for 200 times of its non-pregnant volume. However, the route of conduction of the information of uterine enlargement to the hypothalamus was unknown for 60 years. Recently, 4 research papers reported the presence of nerves between the uterus and brain in rats and mice [2-5], which will play very important role in the formation of labor contractions of uterus [6].

Thus, the preeclampsia will be caused by the stimulation of hypothalamic sympathetic center by the enlarged uterus in the late pregnancy through the nerves innervated between the uterus and the brain.

References

Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 11793
  • [From(publication date):
    February-2014 - Dec 14, 2017]
  • Breakdown by view type
  • HTML page views : 7975
  • PDF downloads : 3818
 

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version