alexa The Promise and Challenge of Digital Biology | OMICS International
ISSN: 2155-9538
Journal of Bioengineering & Biomedical Science

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

The Promise and Challenge of Digital Biology

Mark E Minie1 and Ram Samudrala2*

1Bioengineering Department, University of Washington, USA

2Microbiology Department, University of Washington, USA

*Corresponding Author:
Ram Samudrala
Microbiology Department
University of Washington, USA
Tel: 1-206-732-6122
E-mail: [email protected]

Received Date: November 29, 2013; Accepted Date: November 29, 2013; Published Date: December 04, 2013

Citation: ME Minie, Samudrala R (2013) The Promise and Challenge of Digital Biology. J Bioeng Biomed Sci 3: e118. doi: 10.4172/2155-9538.1000e118

Copyright: © 2013 ME Minie, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Bioengineering & Biomedical Science


The era of Digital Biology began in 2010 with the “rebooting” of a bacterial cell using a synthetic DNA genome created from a digital template stored on a computer [1]. With this event, the creation of Mycoplasma laboratorium (nicknamed “Synthea”), came the first complete proof that DNA was the true software of life. Cells could be simulated digitally and the simulations could be tested against reality by reprograming cytoplasm with synthetic genomes generated from the digital DNA sequences driving those simulations. This in turn has created the expectation and promise that a deeper understanding of cellular function and thus life itself could be achieved on an infinite iterative loop of computer modeling and chemical synthesis (Figure 1) [2].


Figure 1: The digital biology loop, with the digital bioconverter, a tool for instantiating data driven biosimulations into biomolecules and cells for analysis at the lab bench, digitization and further simulation and analysis.

Key components of the digital biology loop are 1) a detailed digital mapping of living systems and their biomolecular parts and the interactions of such parts-biodigitization, 2) accessible databases containing/managing this biodata, 3) computer simulation algorithms of cells driven by digital DNA sequences encoding the biomolecular parts and interactions-biosimulation, 4) laboratory technologies to deeply analyze the resulting synthetic cells-biolab-and finally and centrally 5) the digital biological converter (digital bioconverter for short). In these early days of digital biology, each of these components presents exciting bioengineering, bioscience and biomedical challenges.

Biodigitization and Biodata

Every aspect of Earth’s biosphere is currently being digitized, from the molecular to the planetary levels and the data entered into an evergrowing collection of biologically oriented Internet databases-a mirror backup image of terrestrial life is literally being created (Figure 2A) [3]. The digital acquisition of DNA sequences of phage, viruses, bacteria and human cells, the 3D structures of biomoleculesas well as the detailed cellular structures and tissue and organ architecture has been underway in earnest for more than two decades now. With the advent of molecular imaging, electronic medical records, and “Big Data” [4,5], every aspect of individual organisms, populations, and ecosystems are now also being fed into the Internet based DataStream. Online biological databases are also on track for doubling every 5 years [3,6] (Figure 2B). The sheer volume of such data now threatens to overtake current data storage and search technology, and may require the development of novel technologies, including nucleic acid based data storage [7] and quantum computing [8].


Figure 2: A. Biological data is being acquired at every level of Earth’s biosphere and B. the digitized biodata is being incorporated into Web accessible databases at a doubling rate of once every 5 years (from [6]).

Biosimulation and Biolab

Simulations of cells have been developed over the last two decades[911], but none are specifically driven by digitized DNA genomes from real cells, and their accuracy and relevance remain to be satisfactorily demonstrated. The advent of synthetic biology tools such as Tinkercell [1214] and database driven animation[15] provide strong starts for the tools that will be needed. Detailed electronic images if biomolecules useful in simulations are already readily available from such sources as PubChem and Biosystems [6]. On the other side of the issue, biolab tools for analyzing and manipulating synthetically produced living cells are arising with breathtaking speed. Molecular imaging of structures within living cells is now possible [1619], and even the direct physical manipulation of cellular components using optical tweezers is a routine technique [20]. Additive manufacturing tools now make the construction of artificial biofilms and organs for research a reality [2128] (Figure 3).


Figure 3: A. Components for biosimulation-digitized biodata, digital electronic cell models (E-CELLS), and digital electronic molecular models (E-MOLECULES). B. Biolab tools for analysis-novel cell/viruses on chip systems (ORGANISM-CHIPS), advanced microscopy (IMAGING) and advanced in vitro biochemistry (CELL FREE SYSTEMS).

Digital Bioconverter

The key “gadget” in digital biology, the digital bioconverter (Figure 4), currently exists as a prototype [2] and will likely eventually evolve into a miniaturized commercially produced laboratory instrument. Such a system would allow the convenient production of cells, viruses and biological molecules directly from digitized gene encoding DNA sequences, and eventually could be as central to basic bioscience research as automated DNA sequencers are today. Significant challenges must be met before this is realized, however. While synthesis of large genomes is now possible, it remains complex and expensive. An alternative to cellular transformation could be realized via cell free systems-DNA could be loaded into such systems and then drive the production of biomolecules or organisms through a further instantiation steppossibly through reconstitution of cells and viruses (organisms) from in vitro systems[2932] or the cell free synthesis of biomolecules.


Figure 4: The digital bioconverter, conveying electronic digitized information to the biological realm via DNA.

Grand Synthesis

Increasingly available digitized biodata coupled with advanced biosynthetic synthesis are leading to a new era of biology where electronic digital simulations can be converted to cells and biological molecules-the era of digital biology. While several major engineering and computing challenges must be tackled, these are not insurmountable and are the objects of vigorous technological innovation. In particular, the development of a standardized and commercially available bioconversion device will be critical, and with such a device in eventual widespread use a rapid cycle of model driven understanding of biological systems will get underway. Such a device and the concept of digital biology will have applications in many fields, including astrobiology [3335], medicine [3638], nanotechnology [39], bioinformatics [36,37,4047], drug repurposing [48] and pharmacoengineering [4951], while presenting the promise of placing bioengineering and biomedicine on a Moore’s Law-like curve of exponentially increasing understanding and providing exquisite control of living systems.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Relevant Topics

Recommended Conferences

Article Usage

  • Total views: 12279
  • [From(publication date):
    August-2013 - Jun 19, 2018]
  • Breakdown by view type
  • HTML page views : 8458
  • PDF downloads : 3821

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7