alexa The Use of Sex Pheromone in the Control of the Lutzomyia Longipalpis (Psychodidae: Phlebotominae), the Vector of Leishmania Infantum in the New World | OMICS International
ISSN: 2161-0983
Entomology, Ornithology & Herpetology: Current Research
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The Use of Sex Pheromone in the Control of the Lutzomyia Longipalpis (Psychodidae: Phlebotominae), the Vector of Leishmania Infantum in the New World

Reginaldo Peçanha Brazi*

Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil

*Corresponding Author:
Reginaldo P Brazil
Laboratório de Doenças Parasitárias
Instituto Oswaldo Cruz-Fiocruz
Rio de Janeiro, Brazil
Tel: 021-3865 8134
E-mail: [email protected]

Received date: November 20, 2013; Accepted date: November 21, 2013; Published date: November 28, 2013

Citation: Brazil RP (2013) The Use of Sex Pheromone in the Control of the Lutzomyia Longipalpis (Psychodidae: Phlebotominae), the Vector of Leishmania Infantum in the New World. Entomol Ornithol Herpetol 2:e106. doi: 10.4172/2161-0983.1000e106

Copyright: © 2013 Brazil RP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Visceral Leishmaniasis (VL) is the most severe form of leishmaniasis with high global annual incidence of human cases. This disease is concentrated mainly in India, Bangladesh, Sudan, South Sudan, Ethiopia and Brazil [1] with a significant morbity and mortality in rural and urban areas of Latin America.

The causative agent of VL is the protozoan parasite Leishmania infantum, that is disseminated in the Americas by the sand fly Lutzomyia longipalpis [2] and domestic dogs are the main reservoir of the parasite.

Chemical communications among individual organism in the same species are mediated by pheromones and it has been found across the animal kingdom and highly exploited by insects in a complex system. The most common features mediated by pheromones include attraction of the conspecific sex for mating, aggregating both sexes to a specific site for feeding and/or mating, and marking sites or forming trails [3]. Sex pheromones are chemicals produced either by females to attract males or males to attract females and are widely used in Agriculture for controlling insects pests. Although used with success against insects of commercial interest, virtually very little of this technology have been used against insects of medical interest.

Considered a complex of sibling species, Lutzomyia longipalpis (Figure 1) can be found in different habitats from Central Mexico to northern Argentina with a highly success of dispersion to urban areas [2,4,5]. Lutzomyia longipalpis uses male produced sex pheromones for mate recognition and females recognize and respond to the specific pheromone over a few meters [6]. Males Lutzomyia longipalpis aggregation occurs near or on vertebrate hosts during females’ blood-feeding. Males arrive to the vertebrate hosts, before females, activating attraction to the opposite gender. The sex pheromones of Lutzomyia longipalpis are terpenoid compounds with 16 carbons (Homosesquiterpenes) or 20 carbons [7,8]. With the synthesis of (S)- 9-methylgermacrene-B (Figure 2), the sex pheromone of one of the members of the complex, and its analogue (+/-)-9-methylgermacrene a new possibility was open for the development of novel strategies for mating disruption and consequently, sand fly population management.


Figure 1: Lutzomyia longipalpis males.


Figure 2: Chemical structure of (S)-9-Methylgermacrene-B.

More recently, this new strategy is now been applied in an area of visceral leishmaniasis in Brazil showing the attractiveness of the synthetic sex pheromone to female Lutzomyia longipalpis suggesting a valid alternative for the control of this sand fly in a medium term [9,10].


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