Î±-tocopherol (Î±-T) out of the 8 major analogues of vitamin E has been a particular focus because of its strong antioxidant properties. Î±-T is enriched in the plasma of humans and higher animals 10-100-fold to an average of 23.2 Î¼M. In Vitamin E isomers, Î±-T is a fat-soluble vitamin, where as it phosphate form, Î±-tocopherol phosphate (Î±-TP) is naturally occurring water-soluble form. Î±-T has strong antioxidant activity, the chromanol OH group in Î±-TP is phosphorylated so that it has no antioxidant activity. Î±-TP acts as a detergent forming a barrier which might inhibit the transfer of free radicals from one polyunsaturated fatty acid. Î±-TP more efficiently modulated atherosclerotic and inflammatory events than Î±-T by reducing THP-1 cell proliferation and expression of the CD36 scavenger receptor. Î±-TP and Î±-T act as lipid mediators modulating signal transduction and gene expression.
Michael Eskin NA
Open access OMICS International Publishing Group aimed to provide the readers a barrier free flow of research work and conceptualized knowledge through online. To speed up the pace of scientific innovations, discovery, quality enriched education system and increase the global economy, open access is a key to success in dissemination of knowledge to world community.
Vitamins & Minerals is one such open access journal from OMICS Group, publishing the research, review, case reports, short commentaries and editorials pertaining to the field of nutrition sciences on quarterly basis for its readers. Today in the field of competition, quality of articles publishing in the journal per issue is very important with a rapid peer review process. Vitamins and Minerals journal trying to bring such quality in the articles published per issue with its broader conceptualized editorial board and with the expertise reviewers.
Last date updated on June, 2014