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In this condition, protein deposits of Alpha-synuclein called lewy bodies develop in nerve cells in brain regions involved in memory, reasoning, perception, thinking, behavior and movement. Many people with DLB experience movement symptoms such as hunched posture, rigid muscles, shuffling walk and trouble initiating movement. Lewy body dementia is the second most common kind of dementia after Alzheimer’s disease that gradually causes decline in mental ability. It may sometimes causes visual hallucination and unusual behaviors such as having conversations with deceased loved ones. It sometimes exists in pure form, or with other brain changes, including those commonly observed in Alzheimer's and Parkinson's diseases.
Dementia with Lewy bodies (DLB) is the third most common cause of dementia. It affects about 15% of people with dementia, over 100,000 people in the UK.