Meniere's disease is an inner ear disease that typically only affects one ear. This disease can cause pressure or pain in the ear, severe cases of dizziness or vertigo and a ringing noise, also known astinnitus. People in their 40s and 50s are much more likely to experience it. This condition is considered to be chronic and there is no cure, but there are various treatment strategies that will minimize the effect on one's life.
The pathophysiology of Ménière's disease is not clearly understood. It was previously thought that Ménière's was closely correlated with endolymphatic hydrops, a condition in which endolymph builds up due to an obstruction in the endolymphatic sac. Hormones such as saccin and glycoproteins are produced in excess, which may relieve the blockage and cause vertigo due to the sudden release of endolymph across the sac.
It is estimated at approximately 1 in every 1,000 people suffers from Meniere's disease. The disease can develop at any age, but more commonly does so when the patient is aged between 40 and 60.About 80 % of the patients with a high-risk clinical profile of idiopathic bilateral progressive sensorineural hearing loss have a positive response to immunosuppressive regimen.
There are various diseases that may mimic either one or more symptoms of Meniere’s disease. The vague onset of Meniere’s disease creates a challenge for differential diagnosis, and the ultimate diagnosis may be preceded by several visits to health care units. Autoimmune sensorineural hearing loss was described for the first time by McCabe (1979).
Major research on disease:
Dana White Meniere's Disease: A-Rod, German stem cell treatment cure.Diagnosis to be based on relatively distinct clinical manifestations (progressive sensorineural, usually bilateral but possibly also asymmetric hearing loss over weeks or months) positive immune laboratory tests and a positive treatment response.