Definition: Premature ovarian failure- conjointly referred to as primary gonad insufficiency - refers to a loss of traditional perform of your ovaries before age forty. If your ovaries fail, they do not manufacture traditional amounts of the internal secretion oestrogen or unharness eggs often. Sterility may be a common result.
Signs and symptoms of premature female internal reproductive organ failure square measure almost like those toughened by a lady inquiring climacteric and square measure typical of steroid hormone deficiency. They include: Irregular or skipped periods (amenorrhea), could which can} be gift for years or may develop once a maternity or once stopping contraception pills: Hot flashes, Night sweats, channel condition, Irritability or problem concentrating, attenuate concupiscence
Treatment: If your periods become irregular or stop, your doctor can offer you a physical examination and raise your questions on your general health and whether or not you've got alternative symptoms of primary female internal reproductive organ insufficiency. You’ll even have a bioassay. And your blood is tested for alternative attainable causes of irregular periods. To envision for attainable female internal reproductive organ failure, your blood level of FSH (FSH) are checked. FSH signals your body to unharness associate egg monthly.
Statistics: In United Kingdom, the survey on Premature ovarian failure reveals the result as incidence of ovarian failure in the premenopausal cyclophosphamide treated group was 54% and the incidence of premature menopause (occurring before age 40 years) was 41%. Increasing age at start of treatment showed a linear trend with incidence of ovarian failure (p = 0.01). Using logistic regression, increasing duration of treatment was related to incidence of ovarian failure (p = 0.047 in those treated age 35 years or younger). An association between the lowest neutrophil count throughout the treatment period, when taken immediately before each planned cyclophosphamide pulse, and the incidence of ovarian failure was also demonstrated (p = 0.04 in those treated before age 40 years).